For harnessing the full potential of quantum phenomena, light-matter interfaces and complexly connected quantum networks are required, relying on the joint quantum operation of different physical platforms. In this work, we analyze the quantum properties of multipartite quantum systems, consisting of an arbitrarily large collection of optical cavities with two-level atoms. In particular, we explore quantum walks in such systems and determine the resulting entanglement. Realistic imperfections are included in the model as optical losses and spontaneous decays of atoms. The topology of torus and the non-orientable M"obius strip serve as examples of complex networks we consider, demonstrating the versatility of our approach and resulting in interesting quantum dynamics and interference effects for quantum simulation applications.