This paper will explore the design and implementation of quantum networks in space integrated with quantum networks on Earth. We propose a three-layer approach, involving GEO and LEO satellites integrated with terrestrial ground stations. We first analyze the channel conditions between the three layers, and then highlight the key role of LEO satellites in the integrated space-terrestrial system - namely the source of entanglement distribution between specified terrestrial stations via direct downlink quantum-optical channels. The GEO satellites in the considered system are used primarily as coordination stations, managing and directing the LEO satellites regarding the positioning and timing of entanglement distribution. Complexity, in the form of entanglement distillation and quantum-state correction, is concentrated at the terrestrial stations, and teleportation is used as the primary quantum channel in the LEO uplinks and the inter-terrestrial channels. Although our designs are futuristic in that they assume limited quantum memory at the transceivers, we also discuss some near-term uses of our network in which no quantum memory is available.