We show how to realize a general quantum circuit involving gates between arbitrary pairs of qubits by means of geometrically local quantum operations and efficient classical computation. We prove that circuit-level local stochastic noise modeling an imperfect implementation of our derived schemes is equivalent to local stochastic noise in the original circuit. Our constructions incur a constant-factor increase in the quantum circuit depth and a polynomial overhead in the number of qubits: To execute an arbitrary quantum circuit on (n) qubits, we give a 3D quantum fault-tolerance architecture involving (O(n^{3/2} log^3 n)) qubits, and a quasi-2D architecture using (O(n^2 log^3 n)) qubits. Applied to recent fault-tolerance constructions, this gives a fault-tolerance threshold theorem for universal quantum computations with local operations, a polynomial qubit overhead and a quasi-polylogarithmic depth overhead. More generally, our transformation dispenses with the need for considering the locality of operations when designing schemes for fault-tolerant quantum information processing.