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Statistical Inference After Adaptive Sampling For Longitudinal Data

Abstract

Online reinforcement learning and other adaptive sampling algorithms are increasingly used in digital intervention experiments to optimize treatment delivery for users over time. In this work, we focus on longitudinal user data collected by a large class of adaptive sampling algorithms that are designed to optimize treatment decisions online using accruing data from multiple users. Combining or "pooling" data across users allows adaptive sampling algorithms to potentially learn faster. However, by pooling, these algorithms induce dependence between the sampled user data trajectories; we show that this can cause standard variance estimators for i.i.d. data to underestimate the true variance of common estimators on this data type. We develop novel methods to perform a variety of statistical analyses on such adaptively sampled data via Z-estimation. Specifically, we introduce the \textit\{adaptive\} sandwich variance estimator, a corrected sandwich estimator that leads to consistent varia

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