Abstract
We propose and implement a comprehensive quantum compilation toolkit for solving the maximum independent set (MIS) problem on quantum hardware based on Rydberg atom arrays. Our end-to-end pipeline involves three core components to efficiently map generic MIS instances onto Rydberg arrays with unit-disk connectivity, with modules for graph reduction, hardware compatibility checks, and graph embedding. The first module (reducer) provides hardware-agnostic and deterministic reduction logic that iteratively reduces the problem size via lazy clique removals. We find that real-world networks can typically be reduced by orders of magnitude on sub-second time scales, thus significantly cutting down the eventual load for quantum devices. Moreover, we show that reduction techniques may be an important tool in the ongoing search for potential quantum speedups, given their ability to identify hard problem instances. In particular, for Rydberg-native MIS instances, we observe signatures of an easy-