Abstract
This volume contains the proceedings of the 22nd International Conference on Quantum Physics and Logic (QPL 2025), which was held from 14th to 18th July 2025, in Varna, Bulgaria, organised by Universit\'e libre de Bruxelles. QPL is an annual conference that brings together academic and industry researchers working on the mathematical foundations of quantum computation, quantum physics, and related areas. The main focus is on the use of algebraic and categorical structures, formal languages, semantic methods, as well as other mathematical and computer scientific techniques applicable to the study of physical systems, physical processes, and their composition.