Abstract
There is growing interest in viable quantum theories with PT-symmetric non-Hermitian Hamiltonians, but a formulation of transition matrix elements consistent with positivity and perturbative unitarity has so far proved elusive. This Letter provides such a formulation, which relies crucially on the ability to span the state space in such a way that the interaction and energy eigenstates are orthonormal with respect to the same positive-definite inner product. We apply this non-Hermitian approach to two-neutrino flavour oscillations, and show how it can accommodate the seesaw mechanism.